How To Cite Cancer Cell Line Encyclopedia

How to use cancer cell line encyclopedia.

How to cite cancer cell line encyclopedia.

Efforts for profiling cancer cell lines such as the cancer cell line encyclopedia 33 and the cancer dependency 34 map now include proteomics characterization rppa and ms for a large. You don t need special access or authorization status to use the data in this project. The experiment was performed in multiplex format with 9 biological samples per plex and one common sample to normalize between plexes. The ccle cancer cell line encyclopedia project is a collaboration between the broad institute and the novartis institutes for biomedical research and its genomics institute of the novartis research foundation to conduct a detailed genetic and pharmacologic characterization of a large panel of human cancer models to develop integrated computational analyses that link distinct pharmacologic.

Here we systematically characterize circrnas expression profile in 935 cancer cell lines across 22 cancer lineages from cancer cell line encyclopedia ccle and analyzed the circrnas biogenesis regulators effect of circrnas on drug response and association between circrnas with mrna protein and mutation and predicted rna regulatory element in circrnas. 2012 the cancer cell line encyclopedia enables predictive modelling of anticancer drug sensitivity. The ccle public project contains open access sequencing data in the form of reads aligned to the hg19 broad variant reference genome for nearly 1000 cancer cell line samples as available from cghub on may 11 2016. To further understand the metabolic diversity of cancer we profiled 225 metabolites in 928 cell lines from more than 20 cancer types in the cancer cell line encyclopedia ccle using liquid.

Citation s barretina j et al. In this publication we expand the cancer cell line encyclopedia to include quantitative proteome profiling by mass spectrometry of 375 cell lines from diverse lineages. The cancer cell line encyclopedia is a database of gene expression genotype and drug sensitivity data for human cancer cell lines. From the proteomics community there was interest about how we normalized the data as the.

Mass spectrometry based proteomics data is broadly unfamiliar to most biologists in our experience resulting in questions from analysts about how to use the data. 2020 the broad institute of mit harvard.